Thioredoxin 1 participates in the activity of the Salmonella enterica serovar Typhimurium pathogenicity island 2 type III secretion system.

@article{Negrea2009Thioredoxin1P,
  title={Thioredoxin 1 participates in the activity of the Salmonella enterica serovar Typhimurium pathogenicity island 2 type III secretion system.},
  author={Aurel Negrea and Eva Bjur and Speranta Puiac and Sofia Eriksson Ygberg and Fredrik {\AA}slund and Mikael Rhen},
  journal={Journal of bacteriology},
  year={2009},
  volume={191 22},
  pages={
          6918-27
        }
}
The facultative intracellular pathogen Salmonella enterica serovar Typhimurium relies on its Salmonella pathogenicity island 2 (SPI2) type III secretion system (T3SS) for intracellular replication and virulence. We report that the oxidoreductase thioredoxin 1 (TrxA) and SPI2 are coinduced for expression under in vitro conditions that mimic an intravacuolar environment, that TrxA is needed for proper SPI2 activity under these conditions, and that TrxA is indispensable for SPI2 activity in both… CONTINUE READING
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