Thioredoxin-1, chemokine (C-X-C motif) ligand-9 and interferon-γ expression in the neoplastic cells and macrophages of Hodgkin lymphoma: clinicopathologic correlations and potential prognostic implications.

@article{Vassilakopoulos2017Thioredoxin1C,
  title={Thioredoxin-1, chemokine (C-X-C motif) ligand-9 and interferon-γ expression in the neoplastic cells and macrophages of Hodgkin lymphoma: clinicopathologic correlations and potential prognostic implications.},
  author={Theodoros P Vassilakopoulos and Georgia Levidou and Vassilis Milionis and Sylvia Hartmann and Eleftheria Lakiotaki and Athanasia Sepsa and Irene Thymara and Panagiota Ntailiani and Kallirroi Spanou and Maria K Angelopoulou and Marina P Siakantaris and Maria Moschogiannis and Gerassimos A Pangalis and Panayiotis P. Panayiotidis and Kostas Konstantopoulos and Efstratios S. Patsouris and Martin-Leo Hansmann and Penelope Korkolopoulou},
  journal={Leukemia & lymphoma},
  year={2017},
  volume={58 9},
  pages={1-13}
}
Expression of thioredoxin-1 (TXN) and CXCL9 is not restricted to THRLBCL macrophages, but may be observed in histiocytes and neoplastic (HRS) cells of EBV + mixed cellularity (MC) classical Hodgkin lymphoma (cHL) and nodular lymphocyte predominant HL. We aimed to validate and extend the above observations in 174 cHL patients evaluating the immunohistochemical expression of TXN, CXCL9 and IFN-γ. HRS-cell CXCL9 expression was higher in latent membrane protein-1 (LMP1)+, MC and Stage IV. TXN and… CONTINUE READING