Thioredoxin: a key regulator of cardiovascular homeostasis.

  title={Thioredoxin: a key regulator of cardiovascular homeostasis.},
  author={Hideyuki Yamawaki and Judith Haendeler and Bradford C. Berk},
  journal={Circulation research},
  volume={93 11},
The thioredoxin (TRX) system (TRX, TRX reductase, and NADPH) is a ubiquitous thiol oxidoreductase system that regulates cellular reduction/oxidation (redox) status. The oxidation mechanism for disease pathogenesis states that an imbalance in cell redox state alters function of multiple cell pathways. In this study, we review the essential role for TRX to limit oxidative stress directly via antioxidant effects and indirectly by protein-protein interaction with key signaling molecules, such as… CONTINUE READING