Thiopurines: factors influencing toxicity and response.

  title={Thiopurines: factors influencing toxicity and response.},
  author={Alan Kambiz Fotoohi and Sally A. Coulthard and Freidoun Albertioni},
  journal={Biochemical pharmacology},
  volume={79 9},
Thiopurines are the backbone of current anti-leukemia regimens and have also been effective immunosuppressive agents for the past half a century. Extensive research on their mechanism of action has been undertaken, yet many issues remain to be addressed to resolve unexplained cases of thiopurine toxicity or treatment failure. The aim of this review is to summarize current knowledge of the mechanism of thiopurine action in experimental models and put into context with clinical observations… CONTINUE READING