Thiopurine methyltransferase isozymes in human renal tissue.


Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (6-MP). Levels of TPMT activity in human tissue are controlled by a common genetic polymorphism. On a genetic basis, 88.6% of humans have high, 11.1% have intermediate, and 0.3% have very low or undetectable levels of enzyme activity. Ion exchange… (More)


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@article{Loon1990ThiopurineMI, title={Thiopurine methyltransferase isozymes in human renal tissue.}, author={Jeanne A M van Loon and Richard M. Weinshilboum}, journal={Drug metabolism and disposition: the biological fate of chemicals}, year={1990}, volume={18 5}, pages={632-8} }