Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease.

@article{Ansari2002ThiopurineMA,
  title={Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease.},
  author={A R Ansari and Cesare Hassan and J. Duley and Anthony Marin Marinaki and E-M Shobowale-Bakre and Paul T Seed and John Meenan and A. Yim and Jeremy A Sanderson},
  journal={Alimentary pharmacology & therapeutics},
  year={2002},
  volume={16 10},
  pages={1743-50}
}
BACKGROUND Azathioprine therapy is discontinued in one-third of patients with inflammatory bowel disease because of toxicity or a lack of clinical response. Patients with thiopurine methyltransferase (TPMT) deficiency are intolerant to azathioprine, whilst carriers are at increased risk of side-effects. AIM To evaluate the importance of TPMT activity in the management of azathioprine therapy in inflammatory bowel disease. METHODS Clinical response, adverse effects and haematological… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 90 extracted citations

Efficacy and safety of long-term thiopurine maintenance treatment for ulcerative colitis in Turkey: A single-center experience.

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology • 2018
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…