Thiopurine effectiveness in patients with Crohn's disease: a study of genetic and clinical predictive factors.


BACKGROUND Thiopurines are efficacious in the treatment of Crohn's disease and were recently shown to induce T-cell apoptosis by modulation of Rac1 activation. To assess whether polymorphisms in Rac1 and other apoptosis-related genes, combined with clinical parameters, can predict response to thiopurines. METHODS A retrospective cohort of 156 thiopurine… (More)
DOI: 10.1097/MIB.0b013e31828828d3