Thiopurine drugs in the treatment of childhood leukaemia: the influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity.

@article{Lennard1997ThiopurineDI,
  title={Thiopurine drugs in the treatment of childhood leukaemia: the influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity.},
  author={Lynne Lennard and Jennifer C Welch and John S. Lilleyman},
  journal={British journal of clinical pharmacology},
  year={1997},
  volume={44 5},
  pages={455-61}
}
AIMS The response to 6-mercaptopurine (6MP) is highly variable. Its antileukaemic effect can be related to drug derived 6-thioguanine nucleotides (TGNs). The inherited level of thiopurine methyltransferase (TPMT) activity may be a major factor in the clinical response to 6MP because TPMT forms methylmercaptopurine metabolites (MeMPs) at the expense of TGNs. The aim of this study was to explore the clinical importance of TPMT phenotype. METHODS Thiopurine metabolism was studied in a… CONTINUE READING

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