Thiopurine S-methyltransferase polymorphisms and thiopurine toxicity in treatment of inflammatory bowel disease.

@article{Dong2010ThiopurineSP,
  title={Thiopurine S-methyltransferase polymorphisms and thiopurine toxicity in treatment of inflammatory bowel disease.},
  author={Xian-Wen Dong and Qing Si Zheng and Ming-ming Zhu and Jing-Lu Tong and Zhi-hua Ran},
  journal={World journal of gastroenterology},
  year={2010},
  volume={16 25},
  pages={
          3187-95
        }
}
AIM To evaluate the relationship between thiopurine S-methyltransferase (TPMT) polymorphisms and thiopurine-induced adverse drug reactions (ADRs) in inflammatory bowel disease (IBD). METHODS Eligible articles that compared the frequency of TPMT polymorphisms among thiopurine-tolerant and -intolerant adult IBD patients were included. Statistical analysis was performed with Review Manager 5.0. Sub-analysis/sensitivity analysis was also performed. RESULTS Nine studies that investigated a total… CONTINUE READING
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