Thiopurine S-methyltransferase pharmacogenetics: insights, challenges and future directions

  title={Thiopurine S-methyltransferase pharmacogenetics: insights, challenges and future directions},
  author={Luo Yi Wang and Richard L Weinshilboum},
The thiopurine S-methyltransferase (TPMT) genetic polymorphism is one of the most ‘mature’ examples in pharmacogenetics. That is true because of its importance clinically for the individualization of thiopurine drug therapy and also because TPMT has provided novel insights into molecular mechanisms responsible for the functional effects of common genetic polymorphisms. This review will summarize the development of our understanding of the role of inheritance in the regulation of TPMT as well as… CONTINUE READING

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