Thiophene and bioisostere derivatives as new MMP12 inhibitors.


A new MMP12 inhibitor series has been identified containing a thiophene moiety. Different approaches have been considered to replace this potential toxicophore. α-Fluorothiophene derivatives were the most interesting compounds. Their synthesis is presented. 
DOI: 10.1016/j.bmcl.2010.10.087


Cite this paper

@article{Badland2011ThiopheneAB, title={Thiophene and bioisostere derivatives as new MMP12 inhibitors.}, author={Matthew Badland and Delphine Comp{\`e}re and Karine Court{\'e} and A. Dublanchet and St{\'e}phane Blais and Ajith Manage and Guillaume P{\'e}ron and Roger Wrigglesworth}, journal={Bioorganic & medicinal chemistry letters}, year={2011}, volume={21 1}, pages={528-30} }