Thioperamide, a histamine H3 receptor antagonist, increases GABA release from the rat hypothalamus.

@article{Yamamoto1997ThioperamideAH,
  title={Thioperamide, a histamine H3 receptor antagonist, increases GABA release from the rat hypothalamus.},
  author={Yuki Yamamoto and Toshio Mochizuki and K Okakura-Mochizuki and Atsuhiko Uno and Atsushi Yamatodani},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={1997},
  volume={19 5},
  pages={289-98}
}
Using a microdialysis method and a new high performance liquid chromatography (HPLC)-fluorometric method for the detection of gamma-aminobutyric acid (GABA), we investigated the effect of thioperamide, an H3 receptor antagonist, on the GABA content in the dialysate from the anterior hypothalamic area of rats anesthetized with urethane. The addition of thioperamide to the perfusion fluid increased the release of GABA and histamine. Depleting neuronal histamine with alpha-fluoromethylhistidine, a… CONTINUE READING
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