Thiomersal in Vaccines

  title={Thiomersal in Vaccines},
  author={Mark Bigham and Ray Copes},
  journal={Drug Safety},
A number of affluent countries are moving to eliminate thiomersal (thimerosal), an ethylmercury preservative, from vaccines as a precautionary measure because of concerns about the potential adverse effects of mercury in infants. The WHO advocates continued use of thiomersal-containing vaccines in developing countries because of their effectiveness, safety, low cost, wide availability and logistical suitability in this setting.The guidelines for long-term mercury exposure should not be used for… 

When science is not enough – a risk/benefit profile of thiomersal-containing vaccines

Data is reviewed and summarised that overwhelmingly indicate continued use of thiomersal is safe in those countries where it is most needed, and that there is a real danger that this controversy may result in the loss to the world of thuomersal as a preservative, simply from popular pressure.

Annex 4 Guidelines on regulatory expectations related to the elimination , reduction or replacement of thiomersal in vaccines

  • Biology
  • 2003
Thiomersal (also known as thimerosal, merthiolate) is an organomercurial derivative of ethylmercury that has been used very widely, and for a very long time, as a preservative in vaccines in their

Hair mercury in breast-fed infants exposed to thimerosal-preserved vaccines

It is speculated that dose and parenteral mode of thimerosal-EtHg exposure modulated the relative increase in hair-Hg of breast-fed infants at 6 months of age.

Toxicity of ethylmercury (and Thimerosal): a comparison with methylmercury

In vitro and in vivo studies that compare the toxicological parameters among etHg and other forms of mercury (predominantly meHg) to assess their relative toxicities and potential to cause cumulative insults are reviewed.


In this interview, thiomersal (and its ingredient mercury) used as a preservative in vaccines, has been examined in accompaniance of literature in terms of the autism it may cause.

Safety of thimerosal containing vaccines. Statement of the Consultive Committee of Immunizations on behalf of the Chilean Infectious Diseases Society

After a thorough review of published studies on pediatric use of thimerosal-containing vaccines, and of position papers from international expert groups, the Consultive Committee of Immunizations of the Chilean Society of Infectious Diseases concludes that there is no solid evidence of adverse events associated with the use ofThimerosal containing vaccines in infants and children.

Influenza vaccination: options and issues.

  • S. WongK. Yuen
  • Medicine, Political Science
    Hong Kong medical journal = Xianggang yi xue za zhi
  • 2005
Intradermal injection of the vaccine appears to be a viable alternative to the traditional intramuscular administration with the additional benefit of requiring a smaller volume of vaccine.

Analysis of Mercurial Preservatives in Different Vaccines by Cold Vapor Atomic Absorption Spectrophotometry

Vaccines with low concentration of mercurial preservatives, such as thiomersal, are in use in Albania. A simple and a sensitive method by using CVAAS method for the determination of mercury in



Thiomersal in Vaccines

As a precautionary measure, efforts are under way to remove or replace thiomersal from vaccines and providers should anticipate the availability of more vaccine products that are thiomeric-free over the coming years.

Thiomersal allergy and vaccination reactions

Suggesting that thiomersal hypersensitivity wits not associated with an increased risk of vaccination reactions, however, individual cases of severe reactions to thiomeric demonstrate a need for vaccines with an alternative preservative.

Exposure to thimerosal in vaccines used in Canadian infant immunization programs, with respect to risk of neurodevelopmental disorders.

There are limited data examining the effects of low-dose, intermittent mercury exposure, for example, when infants are immunized with thimerosal-containing vaccines.

The toxicology of mercury--current exposures and clinical manifestations.

Whereas removal of certain forms of mercury, such as that in blood-pressure cuffs, will not cause increased health risks, removal of each of the three major sources described in this article entails health risks and thus poses a dilemma to the health professional.

Methylmercury: a new look at the risks.

In the US, exposure to methylmercury, a neurotoxin, occurs primarily through consumption of fish. Data from recent studies assessing the health impact of methylmercury exposure due to consumption of

Limiting infant exposure to thimerosal in vaccines and other sources of mercury.

Nothing in Medicare’s financial condition compels ending its entitlement to basic-defined coverage at affordable rates. While it is possible to introduce more private insurance options within