Thiomers: potential excipients for non-invasive peptide delivery systems.

@article{BernkopSchnrch2004ThiomersPE,
  title={Thiomers: potential excipients for non-invasive peptide delivery systems.},
  author={Andreas Bernkop-Schn{\"u}rch and Alexander H Krauland and Verena Leitner and Thomas F Palmberger},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2004},
  volume={58 2},
  pages={253-63}
}
In recent years thiolated polymers or so-called thiomers have appeared as a promising alternative in the arena of non-invasive peptide delivery. Thiomers are generated by the immobilisation of thiol-bearing ligands to mucoadhesive polymeric excipients. By formation of disulfide bonds with mucus glycoproteins, the mucoadhesive properties of these polymers are improved up to 130-fold. Due to formation of inter- and intramolecular disulfide bonds within the thiomer itself, dosage forms such as… CONTINUE READING

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