Thiolation and nitrosation of cysteines in biological fluids and cells

  title={Thiolation and nitrosation of cysteines in biological fluids and cells},
  author={Paolo Di Simplicio and Flavia Franconi and Simona Frosali and Danila Di Giuseppe},
  journal={Amino Acids},
 Thiols (RSH) are potent nucleophilic agents, the rates of which depend on the pKa of the sulfhydryl. Unlike compounds having other nucleophile moieties (–OH or –NH2), RSH are involved in reactions, such as conjugations, redox and exchange reactions. Although protein SH groups (PSH) react like non-protein thiols (NPSH), the biochemistry of proteins is much more complex for reasons such as steric hindrance, charge distribution and accessibility of PSH to the solvent (protein conformation). The… CONTINUE READING

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