Thiolated nanostructured lipid carriers as a potential ocular drug delivery system for cyclosporine A: Improving in vivo ocular distribution.

@article{Shen2010ThiolatedNL,
  title={Thiolated nanostructured lipid carriers as a potential ocular drug delivery system for cyclosporine A: Improving in vivo ocular distribution.},
  author={Jie Shen and Yanping Deng and Xuefeng Jin and Qineng Neng Ping and Zhigui Su and Lejun Li},
  journal={International journal of pharmaceutics},
  year={2010},
  volume={402 1-2},
  pages={248-53}
}
Ophthalmic drug delivery with long pre-corneal retention time and high penetration into aqueous humor and intraocular tissues is the key-limiting factor for the treatment of ocular diseases and disorders. Within this study, the conjugate of cysteine-polyethylene glycol monostearate (Cys-PEG-SA) was synthesized and was used to compose the thiolated nanostructured lipid carrier (Cys-NLC) as a potential nanocarrier for the topical ocular administration of cyclosporine A (CyA). The rapid cross… CONTINUE READING
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