Thiolated chitosan nanoparticles for enhancing oral absorption of docetaxel: preparation, in vitro and ex vivo evaluation

@inproceedings{Saremi2011ThiolatedCN,
  title={Thiolated chitosan nanoparticles for enhancing oral absorption of docetaxel: preparation, in vitro and ex vivo evaluation},
  author={Shahrooz Saremi and Fatemeh Atyabi and Seyedeh Parinaz Akhlaghi and Seyed Nasser Ostad and Rassoul Dinarvand},
  booktitle={International journal of nanomedicine},
  year={2011}
}
The aim of this study was to prepare and evaluate mucoadhesive core-shell nanoparticles based on copolymerization of thiolated chitosan coated on poly methyl methacrylate cores as a carrier for oral delivery of docetaxel. Docetaxel-loaded nanoparticles with various concentrations were prepared via a radical emulsion polymerization method using cerium ammonium nitrate as an initiator. The physicochemical properties of the obtained nanoparticles were characterized by: dynamic light-scattering… CONTINUE READING

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