Thiolated Chitosan/DNA Nanocomplexes Exhibit Enhanced and Sustained Gene Delivery

@article{Lee2006ThiolatedCN,
  title={Thiolated Chitosan/DNA Nanocomplexes Exhibit Enhanced and Sustained Gene Delivery},
  author={Dongwon Lee and Weidong Zhang and Shawna A. Shirley and Xiaoyuan Kong and Gary R. Hellermann and Richard F. Lockey and Shyam S Mohapatra},
  journal={Pharmaceutical Research},
  year={2006},
  volume={24},
  pages={157-167}
}
  • Dongwon Lee, Weidong Zhang, +4 authors Shyam S Mohapatra
  • Published in Pharmaceutical Research 2006
  • Medicine, Chemistry
  • PurposeThiolated chitosan appears to possess enhanced mucoadhesiveness and cell penetration properties, however, its potential in gene-drug delivery remains unknown. Herein, we report on a highly effective gene delivery system utilizing a 33-kDa thiol-modified chitosan derivative.MethodsThiolated chitosan was prepared by the reaction with thioglycolic acid. Nanocomplexes of unmodified chitosan or thiolated chitosan with plasmid DNA encoding green fluorescenct protein (GFP) were characterized… CONTINUE READING

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