Thiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis

@inproceedings{Trivedi2016ThiolRS,
  title={Thiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis},
  author={Abhishek Trivedi and Parminder Singh Mavi and Deepak L Bhatt and Ashwani Kumar},
  booktitle={Nature communications},
  year={2016}
}
Mycobacterium tuberculosis (Mtb) forms biofilms harbouring antibiotic-tolerant bacilli in vitro, but the factors that induce biofilm formation and the nature of the extracellular material that holds the cells together are poorly understood. Here we show that intracellular thiol reductive stress (TRS) induces formation of Mtb biofilms in vitro, which harbour drug-tolerant but metabolically active bacteria with unchanged levels of ATP/ADP, NAD(+)/NADH and NADP(+)/NADPH. The development of these… CONTINUE READING
Highly Cited
This paper has 32 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 17 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 17 references

Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition.

Proceedings of the National Academy of Sciences of the United States of America • 2009