Thiol redox disturbances in children with severe asthma are associated with posttranslational modification of the transcription factor nuclear factor (erythroid-derived 2)-like 2.

@article{Fitzpatrick2011ThiolRD,
  title={Thiol redox disturbances in children with severe asthma are associated with posttranslational modification of the transcription factor nuclear factor (erythroid-derived 2)-like 2.},
  author={Anne R. Fitzpatrick and Susan Stephenson and Graham R Hadley and Leandrea Burwell and Madhuri Penugonda and Dawn M. Simon and Jason Hansen and D. H. P. Jones and Lou Ann Scism Brown},
  journal={The Journal of allergy and clinical immunology},
  year={2011},
  volume={127 6},
  pages={1604-11}
}
BACKGROUND Airway thiol redox disturbances, including depletion of the antioxidant, glutathione, are differentiating features of severe asthma in children. OBJECTIVES Given the role of the transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in maintaining glutathione homeostasis and antioxidant defense, we quantified expression and activity of Nrf2 and its downstream targets in the airways and systemic circulation of children with asthma. We hypothesized that Nrf2… CONTINUE READING
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