Thiol redox control via thioredoxin and glutaredoxin systems.

  title={Thiol redox control via thioredoxin and glutaredoxin systems.},
  author={Arne Holmgren and Catrine Johansson and Carsten Berndt and Maria Elisabet L{\"o}nn and Christoph Hudemann and Christopher Horst Lillig},
  journal={Biochemical Society transactions},
  volume={33 Pt 6},
The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive oxygen species signals through thiol redox control mechanisms. Here, we give a brief overview of the human Trx and Grx systems. The main part focuses on our current knowledge about mitochondrial Grx2, which facilitates mitochondrial redox homoeostasis during oxidative stress-induced apoptosis. 
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