Thiol-reactive metal compounds inhibit NF-kappa B activation by blocking I kappa B kinase.

@article{Jeon2000ThiolreactiveMC,
  title={Thiol-reactive metal compounds inhibit NF-kappa B activation by blocking I kappa B kinase.},
  author={K. I. Jeon and J Y Jeong and D. M. Jue},
  journal={Journal of immunology},
  year={2000},
  volume={164 11},
  pages={5981-9}
}
Gold compounds are used in the treatment of rheumatoid arthritis. NF-kappa B is a transcription factor implicated in the expression of many inflammatory genes. NF-kappa B is activated by signal-induced phosphorylation and subsequent degradation of inhibitory I kappa B (inhibitory protein that dissociates from NF-kappa B) proteins, and a multisubunit I kappa B kinase (IKK) has been identified previously. We tested the effect of various gold compounds on the activation of NF-kappa B and IKK in… CONTINUE READING
38 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

Similar Papers

Loading similar papers…