Thiol proteinase expression and pathogenicity of Entamoeba histolytica.

  title={Thiol proteinase expression and pathogenicity of Entamoeba histolytica.},
  author={Sharon L Reed and W E Keene and James H McKerrow},
  journal={Journal of clinical microbiology},
  volume={27 12},
Expression of the 56-kilodalton (kDa) neutral thiol proteinase has been shown to correlate with the potential of clinical isolates of Entamoeba histolytica to produce invasive disease. A 56-kDa band was identified by gelatin substrate gel electrophoresis in 10 of 10 isolates from patients with colitis or amebic liver abscesses, but in only 1 of 10 isolates from asymptomatic patients. Pathogenic isolates appear capable of releasing significantly larger quantities of the proteinase, as measured… CONTINUE READING


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