Thiol groups on the surface of anaerobic parasitic protozoa.

  title={Thiol groups on the surface of anaerobic parasitic protozoa.},
  author={Frances D. Gillin and David S. Reiner and Robert H. Levy and Pierre A. Henkart},
  journal={Molecular and biochemical parasitology},
  volume={13 1},
Evidence is presented that Giardia lamblia and Entamoeba histolytica, phylogenetically unrelated aerotolerant anaerobes, have crucial thiol groups on or easily accessible to their external surface. Both parasites were killed by three structurally unrelated thiol-blocking reagents which penetrate intact cells poorly or not at all. The parasites were protected from p-chloromercuribenzenesulfonic acid (10-100 microM) by cysteine or by reduced glutathione. Killing was arrested with identical… CONTINUE READING

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