Thiol functionalized polymethacrylic acid-based hydrogel microparticles for oral insulin delivery.

@article{Sajeesh2010ThiolFP,
  title={Thiol functionalized polymethacrylic acid-based hydrogel microparticles for oral insulin delivery.},
  author={S. Sajeesh and Christine Vauthier and Claire Gueutin and Gilles Ponchel and Chandra Prakash Sharma},
  journal={Acta biomaterialia},
  year={2010},
  volume={6 8},
  pages={
          3072-80
        }
}
In the present study thiol functionalized polymethacrylic acid-polyethylene glycol-chitosan (PCP)-based hydrogel microparticles were utilized to develop an oral insulin delivery system. Thiol modification was achieved by grafting cysteine to the activated surface carboxyl groups of PCP hydrogels (Cys-PCP). Swelling and insulin loading/release experiments were conducted on these particles. The ability of these particles to inhibit protease enzymes was evaluated under in vitro experimental… CONTINUE READING
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