Thiol dioxygenases: unique families of cupin proteins

  title={Thiol dioxygenases: unique families of cupin proteins},
  author={Martha H. Stipanuk and Chad R Simmons and P. Andrew Karplus and John E. Dominy},
  journal={Amino Acids},
Proteins in the cupin superfamily have a wide range of biological functions in archaea, bacteria and eukaryotes. Although proteins in the cupin superfamily show very low overall sequence similarity, they all contain two short but partially conserved cupin sequence motifs separated by a less conserved intermotif region that varies both in length and amino acid sequence. Furthermore, these proteins all share a common architecture described as a six-stranded β-barrel core, and this canonical cupin… CONTINUE READING


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