Thiol-dependent cathepsins: pathophysiological implications and recent advances in inhibitor design.

@article{Brmme2002ThioldependentCP,
  title={Thiol-dependent cathepsins: pathophysiological implications and recent advances in inhibitor design.},
  author={Dieter Br{\"o}mme and Jadwiga Kaleta},
  journal={Current pharmaceutical design},
  year={2002},
  volume={8 18},
  pages={
          1639-58
        }
}
Thirteen papain-like cysteine proteases (cathepsins) are coded in the human genome from which two represent pseudogenes. Initially it was believed that lysosomal cysteine proteases primarily fulfill house-keeping functions which would exclude them as potential drug targets. Within the last decade, this view has dramatically changed and highly specific and therapeutically relevant functions have been assigned to individual cathepsins. Cathepsins are critical for osteoclast-mediated bone… CONTINUE READING
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