Thiol-based redox switches.

  title={Thiol-based redox switches.},
  author={Bastian Groitl and Ursula Jakob},
  journal={Biochimica et biophysica acta},
  volume={1844 8},
Regulation of protein function through thiol-based redox switches plays an important role in the response and adaptation to local and global changes in the cellular levels of reactive oxygen species (ROS). Redox regulation is used by first responder proteins, such as ROS-specific transcriptional regulators, chaperones or metabolic enzymes to protect cells against mounting levels of oxidants, repair the damage and restore redox homeostasis. Redox regulation of phosphatases and kinases is used to… CONTINUE READING


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