Thiol-based redox switches in eukaryotic proteins.

  title={Thiol-based redox switches in eukaryotic proteins.},
  author={Nicolas Brandes and Sebastian Schmitt and Ursula Jakob},
  journal={Antioxidants & redox signaling},
  volume={11 5},
For many years, oxidative thiol modifications in cytosolic proteins were largely disregarded as in vitro artifacts, and considered unlikely to play significant roles within the reducing environment of the cell. Recent developments in in vivo thiol trapping technology combined with mass spectrometric analysis have now provided convincing evidence that thiol-based redox switches are used as molecular tools in many proteins to regulate their activity in response to reactive oxygen and nitrogen… CONTINUE READING
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