Thiol-based antioxidant supplementation alters human skeletal muscle signaling and attenuates its inflammatory response and recovery after intense eccentric exercise.

@article{Michailidis2013ThiolbasedAS,
  title={Thiol-based antioxidant supplementation alters human skeletal muscle signaling and attenuates its inflammatory response and recovery after intense eccentric exercise.},
  author={Yannis Michailidis and Leonidas G Karagounis and Gerasimos Terzis and Athanasios Z Jamurtas and Kontantinos Spengos and Dimitrios Tsoukas and Athanasios Chatzinikolaou and Dimitrios Mandalidis and Renae J. Stefanetti and Ioannis Papassotiriou and Spyros I. Athanasopoulos and John A. Hawley and Aaron P Russell and Ioannis G Fatouros},
  journal={The American journal of clinical nutrition},
  year={2013},
  volume={98 1},
  pages={233-45}
}
BACKGROUND The major thiol-disulfide couple of reduced glutathione (GSH) and oxidized glutathione is a key regulator of major transcriptional pathways regulating aseptic inflammation and recovery of skeletal muscle after aseptic injury. Antioxidant supplementation may hamper exercise-induced cellular adaptations. OBJECTIVE The objective was to examine how thiol-based antioxidant supplementation affects skeletal muscle's performance and redox-sensitive signaling during the inflammatory and… CONTINUE READING
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