Thiol antioxidants block the activation of antigen-presenting cells by contact sensitizers.

@article{Bruchhausen2003ThiolAB,
  title={Thiol antioxidants block the activation of antigen-presenting cells by contact sensitizers.},
  author={Stefanie Bruchhausen and Sabine Zahn and Elke Valk and Juergen Knop and Detlef Becker},
  journal={The Journal of investigative dermatology},
  year={2003},
  volume={121 5},
  pages={1039-44}
}
Strong contact sensitizers are able to induce signal transduction mechanisms such as tyrosine phosphorylation and activation of MAP kinases in antigen-presenting cells. We studied the capacity of different antioxidants (ascorbic acid, alpha-tocopherol, pyrrolidine dithiocarbamate, N-acetylcysteine, and glutathione) to block the increase in tyrosine… CONTINUE READING