Thiol Probes To Detect Electrophilic Natural Products Based on Their Mechanism of Action.

@article{CastroFalcn2016ThiolPT,
  title={Thiol Probes To Detect Electrophilic Natural Products Based on Their Mechanism of Action.},
  author={Gabriel Castro-Falc{\'o}n and Dongyup Hahn and Daniela Reimer and C. Hughes},
  journal={ACS chemical biology},
  year={2016},
  volume={11 8},
  pages={
          2328-36
        }
}
New methods are urgently needed to find novel natural products as structural leads for the development of new drugs against emerging diseases such as cancer and multiresistant bacterial infections. Here we introduce a reactivity-guided drug discovery approach for electrophilic natural products, a therapeutically relevant class of natural products that covalently modify their cellular targets, in crude extracts. Using carefully designed halogenated aromatic reagents, the process furnishes… Expand
Solid-phase enrichment and analysis of electrophilic natural products
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References

SHOWING 1-10 OF 76 REFERENCES
Electrophilic natural products and their biological targets.
Protein-reactive natural products.
...
1
2
3
4
5
...