Thiol/Disulfide redox switches in the regulation of heme binding to proteins.

  title={Thiol/Disulfide redox switches in the regulation of heme binding to proteins.},
  author={Stephen W Ragsdale and L. J. Yi},
  journal={Antioxidants & redox signaling},
  volume={14 6},
This review focuses on thiol/disulfide redox switches that regulate heme binding to proteins and modulate their activities. The importance of redox switches in metabolic regulation and the general mechanism by which redox switches modulate activity are discussed. Methods are described to characterize heme-binding sites and to assess their physiological relevance. For thiol/disulfide interconversion to regulate activity of a system, the redox process must be reversible at the ambient redox… CONTINUE READING
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