Thioether metabolites of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine inhibit human serotonin transporter (hSERT) function and simultaneously stimulate dopamine uptake into hSERT-expressing SK-N-MC cells.

@article{Jones2004ThioetherMO,
  title={Thioether metabolites of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine inhibit human serotonin transporter (hSERT) function and simultaneously stimulate dopamine uptake into hSERT-expressing SK-N-MC cells.},
  author={Douglas C. Jones and Serrine S. Lau and Terrence J. Monks},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2004},
  volume={311 1},
  pages={
          298-306
        }
}
  • Douglas C. Jones, Serrine S. Lau, Terrence J. Monks
  • Published in
    The Journal of pharmacology…
    2004
  • Chemistry, Medicine
  • 3,4-Methylenedioxyamphetamine (MDA) and 3,4-methyl-enedioxymethamphetamine (MDMA, ecstasy) are widely abused amphetamine derivatives that target the serotonin system. The serotonergic neurotoxicity of MDA and MDMA seems dependent on their systemic metabolism. 5-(Glutathion-S-yl)-alpha-methyldopamine [5-(GSyl)-alpha-MeDA] and 2,5-bis(glutathion-S-yl)-alpha-methyldopamine [2,5-bis(GSyl)-alpha-MeDA], metabolites of MDA and MDMA, are also selective serotonergic neurotoxicants and produce behavioral… CONTINUE READING

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