Thioesterases: a new perspective based on their primary and tertiary structures.

@article{Cantu2010ThioesterasesAN,
  title={Thioesterases: a new perspective based on their primary and tertiary structures.},
  author={David C. Cantu and Yingfei Chen and Peter J. Reilly},
  journal={Protein science : a publication of the Protein Society},
  year={2010},
  volume={19 7},
  pages={
          1281-95
        }
}
Thioesterases (TEs) are classified into EC 3.1.2.1 through EC 3.1.2.27 based on their activities on different substrates, with many remaining unclassified (EC 3.1.2.-). Analysis of primary and tertiary structures of known TEs casts a new light on this enzyme group. We used strong primary sequence conservation based on experimentally proved proteins as the main criterion, followed by verification with tertiary structure superpositions, mechanisms, and catalytic residue positions, to accurately… CONTINUE READING
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