Thiocyanate transport in resting and IL-4-stimulated human bronchial epithelial cells: role of pendrin and anion channels.

@article{Pedemonte2007ThiocyanateTI,
  title={Thiocyanate transport in resting and IL-4-stimulated human bronchial epithelial cells: role of pendrin and anion channels.},
  author={Nicoletta Pedemonte and Emanuela Caci and Elvira Sondo and Antonella Caputo and Kerry J. Rhoden and Ulrich Pfeffer and Michele Di Candia and Roberto Bandettini and Roberto Ravazzolo and Olga Zegarra-Moran and Luis J. V. Galietta},
  journal={Journal of immunology},
  year={2007},
  volume={178 8},
  pages={
          5144-53
        }
}
SCN(-) (thiocyanate) is an important physiological anion involved in innate defense of mucosal surfaces. SCN(-) is oxidized by H(2)O(2), a reaction catalyzed by lactoperoxidase, to produce OSCN(-) (hypothiocyanite), a molecule with antimicrobial activity. Given the importance of the availability of SCN(-) in the airway surface fluid, we studied transepithelial SCN(-) transport in the human bronchial epithelium. We found evidence for at least three mechanisms for basolateral to apical SCN… CONTINUE READING

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