Thiocyanate stabilizes AMPA binding to the quisqualate receptor.

  title={Thiocyanate stabilizes AMPA binding to the quisqualate receptor.},
  author={Elsebet O Nielsen and Joo H Cha and Tage Honor{\'e} and John B. Penney and Anne B. Young},
  journal={European journal of pharmacology},
  volume={157 2-3},
Calcium and chloride ions stimulated [3H]glutamate binding to quisqualate-sensitive [3H]glutamate binding sites 4-fold, as measured by quantitative autoradiography, whereas 100 mM potassium thiocyanate had no additional effect. In contrast, calcium and chloride had little effect on the binding of [3H](RS)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid ([3H]AMPA), but 100 mM thiocyanate stimulated binding 4-fold. AMPA displaced little [3H]glutamate binding from quisqualate-sensitive… CONTINUE READING
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