Thiocyanate induces vasoconstriction in rat-tail artery primed with norepinephrine.

The vasoregulating effects of thiocyanate (SCN-) were studied by means of a new rat tail artery perfusion model that uses constant driving pressure (1000 mm H2O). When a 30 mm long artery was perfused with 20 micromol/L verapamil, the flow rate increased 6%. Norepinephrine (10 to 1000 nmol/L) caused a dose-dependent flow inhibition. SCN- alone (0.05 to 5… (More)