Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects.

@article{Kim2000ThioAO,
  title={Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects.},
  author={Kyoung Soon Kim and John S. Sack and J. S. Tokarski and Ligang Qian and Sam T Chao and Leslie Leith and Yvonne Kelly and Raj N Misra and John T. Hunt and S David Kimball and W Griffith Humphreys and Barri S Wautlet and Janet G Mulheron and Kevin R Webster},
  journal={Journal of medicinal chemistry},
  year={2000},
  volume={43 22},
  pages={4126-34}
}
Flavopiridol analogues, thio- and oxoflavopiridols which contain a sulfur (16) or oxygen (18) atom linker between a chromone ring and the hydrophobic side chain, are selective cyclin-dependent kinase 1 (CDK1) inhibitors with an IC(50) of 110 and 130 nM. These analogues were prepared from key intermediate 7 by substituting the ethyl sulfoxide. Enantio pure intermediate piperidone 10 was obtained from the racemic piperidone 8 via a very efficient "dynamic kinetic resolution" in 76% yield… CONTINUE READING

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