Thinning of the cerebral cortex visualized in HIV/AIDS reflects CD4+ T lymphocyte decline.

@article{Thompson2005ThinningOT,
  title={Thinning of the cerebral cortex visualized in HIV/AIDS reflects CD4+ T lymphocyte decline.},
  author={Paul M. Thompson and Rebecca A. Dutton and Kiralee M. Hayashi and Arthur W. Toga and Oscar L. Lopez and H J Aizenstein and James T. Becker},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 43},
  pages={15647-52}
}
HIV/AIDS infection is the fourth leading cause of death worldwide, and one in every 100 adults aged 15-49 years is HIV-infected. Forty percent of AIDS patients suffer from neurological symptoms, but the selective profile of damage caused by HIV in the brain is not well understood. Here, we report 3D maps revealing how AIDS affects the human cerebral cortex, identifying the most vulnerable regions and where deficits link with cognitive decline and immune-system suppression. With high-resolution… CONTINUE READING
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