Thinning of the Cerebral Cortex in Aging David H. Salat

  title={Thinning of the Cerebral Cortex in Aging David H. Salat},
  author={Randy L. Buckner and Abraham Z. Snyder and Douglas N. Greve and Rahul S. Desikan and Evelina Busa and John C. Morris and Anders M. Dale and Bruce Fischl and Athinoula A. Martinos},
The thickness of the cerebral cortex was measured in 106 nondemented participants ranging in age from 18 to 93 years. For each participant, multiple acquisitions of structural T1-weighted magnetic resonance imaging (MRI) scans were averaged to yield high-resolution, high-contrast data sets. Cortical thickness was estimated as the distance between the gray/white boundary and the outer cortical surface, resulting in a continuous estimate across the cortical mantle. Global thinning was apparent by… CONTINUE READING