Thinning of sensorimotor cortices in children with Tourette syndrome

  title={Thinning of sensorimotor cortices in children with Tourette syndrome},
  author={Elizabeth R. Sowell and E. S. Kan and June Yoshii and Paul M. Thompson and Ravi Bansal and Dongrong Xu and Arthur W. Toga and Bradley S. Peterson},
  journal={Nature Neuroscience},
The basal ganglia portions of cortico-striato-thalamo-cortical (CSTC) circuits have consistently been implicated in the pathogenesis of Tourette syndrome, whereas motor and sensorimotor cortices in these circuits have been relatively overlooked. Using magnetic resonance imaging, we detected cortical thinning in frontal and parietal lobes in groups of Tourette syndrome children relative to controls. This thinning was most prominent in ventral portions of the sensory and motor homunculi that… CONTINUE READING

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