Thinking within the D box: initial identification of Cdh1-APC substrates in the nervous system.

@article{Kim2007ThinkingWT,
  title={Thinking within the D box: initial identification of Cdh1-APC substrates in the nervous system.},
  author={Albert H. Kim and Azad Bonni},
  journal={Molecular and cellular neurosciences},
  year={2007},
  volume={34 3},
  pages={281-7}
}
The anaphase-promoting complex (APC) has a well-established role in cell cycle control, but recent exciting evidence has uncovered unexpected neurobiological functions for this complex E3 ubiquitin ligase. With its co-activator Cdh1, APC's effects upon the nervous system range from regulation of axon growth and patterning to development of synapses to neuronal survival. The Cdh1-APC substrates that control these biological processes in neurons are just beginning to be identified. These findings… CONTINUE READING

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