Thinking clearly about the endophenotype-intermediate phenotype-biomarker distinctions in developmental psychopathology research.

@article{Lenzenweger2013ThinkingCA,
  title={Thinking clearly about the endophenotype-intermediate phenotype-biomarker distinctions in developmental psychopathology research.},
  author={Mark F. Lenzenweger},
  journal={Development and psychopathology},
  year={2013},
  volume={25 4 Pt 2},
  pages={1347-57}
}
The endophenotype is central to modern developmental psychopathology studies. It is used in studies seeking to connect the genetic substrates of the panoply of major mental disorders with processes, tapped by laboratory and other assessment measures, in the genotype to a behavior/psychopathology pathway. Proposed originally by Gottesman and Shields (1972; Shields & Gottesman, 1973) 41 years ago, the endophenotype concept has gained widespread traction in psychopathology research since the… CONTINUE READING