Thin-layer densitometric determination of muzolimine (BAY g 2821), a structurally new diuretic drug, at the nanogram level in biological fluids.

@article{Ritter1977ThinlayerDD,
  title={Thin-layer densitometric determination of muzolimine (BAY g 2821), a structurally new diuretic drug, at the nanogram level in biological fluids.},
  author={W. Ritter},
  journal={Journal of chromatography},
  year={1977},
  volume={142},
  pages={431-40}
}
  • W. Ritter
  • Published 1977 in Journal of chromatography
A sensitive and specific thin-layer densitometric method was developed for the determination of muzolimine (BAY g 2821), a structurally new diuretic drug of the pyrazolinone type. For detection of the drug on thin-layer chromatographic plates, a colour reaction with 4-dimethylaminocinnamaldehyde is carried out. The detection limit was 50 pg per spot on commercially available silica gel 60 plates. A nearly linear relationship between integrated peak area and amount per spot was obtained in the… CONTINUE READING