Thin filament near-neighbour regulatory unit interactions affect rabbit skeletal muscle steady-state force-Ca(2+) relations.

@article{Regnier2002ThinFN,
  title={Thin filament near-neighbour regulatory unit interactions affect rabbit skeletal muscle steady-state force-Ca(2+) relations.},
  author={Michael Regnier and Anthony J Rivera and Chien-Kao Wang and Mandy A Bates and P. Bryant Chase and Albert M. Gordon},
  journal={The Journal of physiology},
  year={2002},
  volume={540 Pt 2},
  pages={485-97}
}
The role of cooperative interactions between individual structural regulatory units (SUs) of thin filaments (7 actin monomers : 1 tropomyosin : 1 troponin complex) on steady-state Ca(2+)-activated force was studied. Native troponin C (TnC) was extracted from single, de-membranated rabbit psoas fibres and replaced by mixtures of purified rabbit skeletal TnC (sTnC) and recombinant rabbit sTnC (D27A, D63A), which contains mutations that disrupt Ca(2+) coordination at N-terminal sites I and II… CONTINUE READING

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