Thin filament mutations: developing an integrative approach to a complex disorder.

@article{Tardiff2011ThinFM,
  title={Thin filament mutations: developing an integrative approach to a complex disorder.},
  author={Jil C. Tardiff},
  journal={Circulation research},
  year={2011},
  volume={108 6},
  pages={765-82}
}
Sixteen years ago, mutations in cardiac troponin (Tn)T and α-tropomyosin were linked to familial hypertrophic cardiomyopathy, thus transforming the disorder from a disease of the β-myosin heavy chain to a disease of the cardiac sarcomere. From the outset, studies suggested that mutations in the regulatory thin filament caused a complex, heterogeneous pattern of ventricular remodeling with wide variations in clinical expression. To date, the clinical heterogeneity is well matched by an extensive… CONTINUE READING

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