Thin-Layer Chromatography of Cardiac Drugs

  title={Thin-Layer Chromatography of Cardiac Drugs},
  author={R. Petras},


RP-TLC Separation of Antiarrhythmic Drugs. Densitometric Analysis of Flecainide in Tablets
The chromatographic behavior of some antiarrhythmic compounds has been studied on commercially available TLC plates coated with octylsilane and octadecylsilane silica gel (RP-C8 and RP-C18,Expand
Validated HPTLC methods for quantification of mexiletine hydrochloride in a pharmaceutical formulation.
Two simple, accurate, and precise HPTLC methods have been established for the determination of mexiletine hydrochloride, an antiarrhythmic agent, in Mexicord capsules by validated in accordance with International Conference on Harmonization guidelines. Expand
Normal and Reversed-Phase Thin-Layer Chromatography in the Analysis of l-Arginine, its Metabolites, and Selected Drugs
Simple, rapid and selective NP-TLC and RP-TLC methods are described for analysis of l-arginine, its primary metabolites (l-cit-rulline, l-glutamine, l-ornithine, asymmetric NG,NG-dimethyl-l-arginine,Expand
RPTLC Retention Indices of Basic and Neutral Drugs as Surrogates of Octanol—Water Distribution Coefficients. Effect of Buffer Constituents and pH
The reversed-phase TLC retention behavior of 26 structurally diverse basic and neutral drugs has been investigated under different chromatographic conditions by varying the aqueous component and pHExpand
Separation and Determination of PETN and TNT by HPTLC
High-performance thin layer chromatography (HPTLC) has been used for the separation and quantification of 2,4,6-trinitrotoluene (TNT) and pentaerythritol tetranitrate (PETN). The compounds wereExpand
Effect of plantain on therapeutic drug monitoring of digoxin and thirteen other common drugs
The plantain products studied did not interfere with therapeutic drug monitoring of digoxin as well as 13 other commonly monitored drugs and did not affect immunoassay results of the 13 other drugs studied. Expand
Stability-indicating methods for the determination of disopyramide phosphate.
The 4 proposed methods were found to be specific for disopyramide phosphate in presence of up to 80% of its degradation product for the spectrophotometric methods, 90% ofIts degradation for the densitometric method, and 40% for the ISE method. Expand
Use of HPTLC, HPLC, and Densitometry for Qualitative Separation of Indole Alkaloids from Rauvolfia serpentina Roots
High-performance thin-layer chromatography (HPTLC) has been used for normal-phase separation of the components of hexane, chloroform, methanol, and water extracts of Rauvolfia serpentina roots.Expand
Normal-Phase TLC Separation of Some Antiarrhythmics. Densitometric Determination of Mexiletine Hydrochloride in Capsules
A normal-phase (NP) TLC method has been established for separation of the five antiarrhythmics - disopyramide, flecainide, mexile-tine, tocainide, and verapamil. The analysis was performed inExpand
Screening for basic drugs in 2-mL urine samples by dual-plate overpressured layer chromatography and comparison with gas chromatography-mass spectrometry.
The OPLC method provides an alternative for current planar and column liquid chromatographic drug screening methods with the possibility of lowering detection limits by using a larger sample size. Expand