Thimerosal induces TH2 responses via influencing cytokine secretion by human dendritic cells

@article{Agrawal2007ThimerosalIT,
  title={Thimerosal induces TH2 responses via influencing cytokine secretion by human dendritic cells},
  author={Anshu Agrawal and Poonam Kaushal and Sudhanshu Agrawal and Sastry V. S. Gollapudi and Sudhir Gupta},
  journal={Journal of Leukocyte Biology},
  year={2007},
  volume={81}
}
Thimerosal is an organic mercury compound that is used as a preservative in vaccines and pharmaceutical products. Recent studies have shown a TH2‐skewing effect of mercury, although the underlying mechanisms have not been identified. In this study, we investigated whether thimerosal can exercise a TH2‐promoting effect through modulation of functions of dendritic cells (DC). Thimerosal, in a concentration‐dependent manner, inhibited the secretion of LPS‐induced proinflammatory cytokines TNF… 
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