Thimerosal decreases TRPV1 activity by oxidation of extracellular sulfhydryl residues

@article{Jin2004ThimerosalDT,
  title={Thimerosal decreases TRPV1 activity by oxidation of extracellular sulfhydryl residues},
  author={Yunju Jin and Dong Kwan Kim and Lee-Yong Khil and Uhtaek Oh and Jiyeon Kwak},
  journal={Neuroscience Letters},
  year={2004},
  volume={369},
  pages={250-255}
}
TRPV1, a receptor for capsaicin, plays a key role in mediating thermal and inflammatory pain. Because the modulation of ion channels by the cellular redox state is a significant determinant of channel function, we investigated the effects of sulfhydryl modification on the activity of TRPV1. Thimerosal, which oxidizes sulfhydryls, blocked the capsaicin-activated inward current (I(cap)) in cultured sensory neurons, in a reversible and dose-dependent manner, which was prevented by the co… CONTINUE READING
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